Simultaneous microdetermination of homovanillic acid and 5-hydroxyindoleacetic acid in biological material

Cerebrospinal homovanillic acid and 5-hydroxyindoleacetic acid in huntington's chorea.

Effect of folic acid by mouth on cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentration.

Administration of 30 mg folic acid by mouth caused a significant fall in cerebrospinal fluid homovanillic acid concentration in 11 subjects. There was no significant change of 5-hydroxyindoleacetic acid concentration. The fall was less marked in five patients on anticonvulsant medication and failed to reach statistical significance. Neither homovanillic acid nor 5-hydroxyindoleacetic acid conce...

Parallel variation of homovanillic acid, 5-hydroxyindoleacetic acid and cyclic adenosine-3, 5-monophosphate in ventricular cerebrospinal fluid of man.

Ventricular cerebrospinal fluid (CSF) values of homovanillic acid (HV A), 5-hydroxyindoleacetic acid (5-HIAA) and cyclic adenosine-3, 5-monophosphate (cAMP) were determined every 2 or 3 hours over a period of 1 to 3 days in 4 patients, consisting of two cases of meningitis, one case of head injury and one case of cerebral aneurysm. Ventricular CSF samples were collected through a drainage tube ...

Cerebrospinal fluid adenosine 3',5'-monophosphate, 5-hydroxyindoleacetic acid and homovanillic acid in patients with sleep apnoea syndrome.

Adenosine 3',5'-monophosphate (cyclic AMP), 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were determined in the cerebrospinal fluid of patients with respiratory disorder and hypersomnia and in control patients. Patients with the sleep apnoea syndrome confirmed polygraphically showed elevated levels of cyclic AMP and 5-HIAA. Cyclic AMP levels were inversely correlated with art...

Concentrations of homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid from human infants in the perinatal period.

To assess maturation of central serotonin and catecholamine pathways at birth, we measured lumbar CSF homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), stable acid metabolites of dopamine and serotonin, using HPLC with electrochemical detection. CSFs from 57 neonates (38 premature and 19 at term) and 13 infants 1-6 months old were studied. HVA levels increased with maturity (p le...